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frictional keratosis on tongue

This frictional keratotic line shows a roughened surface. Frictional keratosis is a white, keratotic lesion due to chronic mechanical irritation caused by sharp edges of teeth or restorations, dental prosthesis, abrasive foods, vigorous tooth brushing, and playing wind instruments. Courtesy of Catherine M. Flaitz, DDS and Alfredo Aguirre, DDS. MeSH terms Adolescent Adult Age Distribution Aged Aged, 80 and over Greer RO., Jr Oral manifestations of smokeless tobacco use. . Woo SB, Lin D. Morsicatio mucosae orisa chronic oral frictional keratosis, not a leukoplakia. Oral Surg Oral Med Oral Pathol. Definition Frictional keratosis is a white, keratotic lesion due to chronic mechanical irritation caused by sharp edges of teeth or restorations, dental prosthesis, abrasive foods, vigorous tooth brushing, and playing wind instruments. Bookshelf So this may cause a white line to appear inside the check side of your mouth it usually disappears over a period of time if the cause is removed, if it is a malaligned teeth, correction of the. Perivascular inflammation composed of lymphocytes and plasma cells are observed in the deeper lamina propria. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. [20] Occasionally, ill-fitting or broken mouthguards or occlusal splints irritate the oral mucosa, resulting in frictional keratosis. Histologic features of WSN are distinct with prominent parakeratosis and acanthosis and clearing of the spinous cell layer (Fig. Nonetheless, this condition should be treated during its initial stages to achieve best results. 2012 Winter;83(1):13, 16. A review of the prior biopsy of the affected mucosa revealed an irregularly hyperplastic epithelium with foci of ballooned epithelial cells within the upper layer, parakeratosis, and bacterial overgrowth (Figure 2). In Seborrheic keratosis is a very common skin condition. Most of these lesions are incidental findings and relate to a variety of causes including parafunctional habits, mechanical friction, contact reactions, chemical-related changes, and tobacco-related changes [25]. Frictional keratosis is a skin growth that can result from mild mechanical trauma or irritation of the skin. I'm hoping it's some sort of frictional keratosis but I'm not aware of me doing . This lesion should quickly resolve after removal of the provoking stimulus. The surface of a lesion may appear irregular and feel rough to the tongue. Natarajan E, Woo SB. (Photographs courtesy of Dr. Hans Grossniklaus). Sucking on the cheeks, lips, or sides of the tongue may be a habit to relieve the discomfort from temporomandibular disorder or burning mouth syndrome. 119(6):484-8, 490-2, 494-503. [QxMD MEDLINE Link]. Bacteria is usually present on the keratin surface in biopsies from the tongue, but not as often on the buccal mucosa or lip. In North American, moist smokeless tobacco is usually placed in the lower buccal vestibule or chewed if chewing tobacco is used. [QxMD MEDLINE Link]. Bethesda, MD 20894, Web Policies Diagnosis : Frictional Hyperkeratosis di mukosa bukal kiri Diagnosis Banding : Cheek Biting, Linea Alba, White Sponge, Nevus, Lichen Planus, Leukodema, Leukoplakia, dan Smokeless Tobacco Keratosis 3. Mravak-Stipeti M, Lonar-Brzak B, Bakale-Hodak I, Sabol I, Seiwerth S, Majstorovi M, Grce M. Clinicopathologic correlation of oral lichen planus and oral lichenoid lesions: a preliminary study. 2015 Dec. 34 (4):161-70. The mostly associated symptoms of this condition include the hyperkeratosis and porokeratosis that appear and can be seen. The epithelium exhibits epithelial hyperplasia and intracellular edema is common presenting as ballooned cells in the spinous layer. Frictional keratosis can also be avoided in a number of ways. Leukoplakia is a clinical term reserved for white lesions that cannot be characterized clinically or pathologically as any other disease (ie, frictional keratosis, lichen planus, candidiasis,. WSN is inherited as an autosomal dominant trait that presents as asymptomatic thickened soft white plaques most commonly on the buccal mucosa (Fig. 7-1a) [8, 12, 26]. However, using clinical features to classify lesions is difficult because they vary in appearance and are likely to be interpreted subjectively by the clinician. [Guideline] Rethman MP, Carpenter W, Cohen EE, et al. Case of the month. Fast Five Quiz: What Do You Know About Dental Health? Michael J Wells, MD, FAAD Dermatologic/Mohs Surgeon, The Surgery Center at Plano Dermatology Signs and Symptoms of Leukoplakia. The clinical findings are critical in helping to distinguish between reactive keratosis and OPMD. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA3NjA4OS1jbGluaWNhbA==. Classification schemes for lesions of the oral cavity typically have used the clinical appearance of lesions to determine which are premalignant. Community Dent Oral Epidemiol. The most important management protocol includes the following: Establish a diagnosis. b A more advanced lesion demonstrates obvious mucosal thickening and wrinkling of the mucosa with intervening furrows. Careers. Steroids are administered to help with the symptoms of Oral Lichen Planus. Snuff dippers keratosis or snuff pouch. 10(2):114-5. Interface mucositis is identified, and the superficial connective tissue contains a predominately lymphocytic band-like inflammatory cell infiltrate which includes plasma cells, histiocytes and scattered eosinophils (Fig. If the cause of the white patches is a precancerous . Oral frictional hyperkeratosis of the attached maxillary gingiva from inappropriate toothbrushing technique. The retromolar pad and edentulous alveolar ridge can exhibit benign keratosis as the area is susceptible to both masticatory forces, occlusal trauma or ill-fitting dentures or other dental appliances (Fig. Leukoedema affects the bilateral buccal and labial mucosa and appears as an opalescent, filmy gray to white lesion that characteristically diminishes upon stretching of the mucosa (Fig. 8a) [32, 35]. Frictional keratosis from the alveolar ridge usually is surfaced by orthokeratin with a slightly irregular or corrugated architecture (Fig. 2000 Nov-Dec. 22(6):511-2. Oral Dis. Oral and Maxillofacial Pathology. J Am Acad Dermatol. Is alveolar ridge keratosis a true leukoplakia? It can be triggered by allergies, irritating chemicals and other factors. Sloan P, Gale N, Hunter K, et al. Tongue lacerations can also result in scarring or swelling. Cummings TJ, Dodd LG, Eedes CR, Klintworth GK. In: el-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, et al., editors. This occurs mostly in the mouth area. 8d). 6b) [24]. Epidemiological evidence relating snus to healthan updated review based on recent publications. Leukoplakia is a patch that is white to gray in color. This friction mostly is from the teeth and dentures. Flaitz CM. Lesions associated with a tongue thrusting habit often demonstrate prominent crenations of the lateral tongue. 15(4):43-8. 7-2a) [30, 31]. 7-1c) [29]. These deposits can be seen around nerves, vessels, salivary glands, and at the epithelial-stroma interface. PVL lesions histologically can have a varied appearance and usually corresponds to the clinical appearance. It may affect any area of the mouth such as the tongue, roof of the mouth, gums and the insides of the cheek. Perivascular inflammation in the deeper lamina propria is present, a feature not typical for oral lichen planus (H&E magnification 40). Semin Cutan Med Surg. Time is the main characteristic that separates an oral . Cinnamon is used a wide array of products such as toothpaste, mouthwash, gum, candy and soft drinks. 141(5):509-20. A 2-month-old girl was referred for evaluation of a well-demarcated, nonsloughing white keratotic plaque of the lower lip mucosa, just inside the vermilion border. Cam K, Santoro A, Lee JB. As the name suggests these patches occur due to friction or . This occurs on the maxillary and mandibular alveolar ridges particularly after extraction of teeth, and particularly in the area of extracted mandibular third molars on the retromolar pad area. A thicker patch of mucosa is at the anterior end (under the tongue blade edge). Courtesy of Catherine M. Flaitz, DDS and Alfredo Aguirre, DDS. 1d). Contact stomatitis. The connective tissue is uninflamed. The gingiva is the most common site for PVL and in a 2014 systematic review of PVL, the gingiva was the most common site for malignant transformation [11]. These white patches are associated with either a conscious or an unconscious chronic oral habit. Courtesy of Catherine M. Flaitz, DDS and Alfredo Aguirre, DDS. [QxMD MEDLINE Link]. Results from periodic acid-Schiffstain revealed no fungal elements. Occasionally, patchy erythema with or without petechiae is observed with recent trauma to the site. frictional keratosis), an oral potentially malignant disorder (e.g. When the frictional component is removed, the lesion will subside. INCIDENCE Frictional keratosis is common. the keratinized epithelium is consist of 4 layers which are basal cell layer , prickle cell layer , granular cell layer and cornified celllayer , but non keratinized epithelium is consist of 3 layers only which are the . Toothpaste-related oral lesions. The lesions usually present on the buccal mucosa or tongue where prolonged contact of the mucosa with the amalgam occur. Without appropriate clinical information these lesions should be diagnosed not as frictional keratoses but as keratoses without dysplasia or as keratosis of unknown significance [13]. Most cases of cinnamon stomatitis are associated with prolonged contact of the offending agent. Haisley-Royster CA, Allingham RR, Klintworth GK, Prose NS. Consult privately with the doctor of your choice. FOIA K13.29 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Both triclosan, an antimicrobial agent, and sodium pyrophosphate are added to toothpaste either as a single ingredient or combined in tartar-control toothpaste to prevent plaque development. Such keratosis conditions as oral frictional keratosis do not affect ones health to a great extent. White sponge nevus: report of a three-generation family. 16:39-78; discussion 79. HBID is characterized histopathologically by hyperplastic stratified squamous epithelium with marked parakeratosis and acanthosis (Fig. Diagnosis : Geographic Tongue (Erythema Migrans) Diagnosis Banding : Erythematous Candidiasis, Lichen Planus, Lupus Erythematosus, dan Leukoplakia 4. Apart from altering the beauty of the mouth, this white patch has no problems associated with it. Bouquot JE, Gorlin RJ. Biopsies should be performed on these lesions that do not heal to rule out a Amalgam contact reactions have clinical overlap with oral lichen planus, but unlike lichen planus, contact reactions to amalgam are usually single and can resolve upon amalgam removal [8, 12]. 2005 Nov 12. Head Neck Pathol. 3rd ed. Various names have been used to describe particular examples of frictional keratosis (FK). Jeff Burgess, DDS, MSD (Retired) Clinical Assistant Professor, Department of Oral Medicine, University of Washington School of Dental Medicine; (Retired) Attending in Pain Center, University of Washington Medical Center; (Retired) Private Practice in Hawaii and Washington; Director, Oral Care Research AssociatesDisclosure: Nothing to disclose. 2012 Mar-Apr. 1c) [9, 10]. . The connective tissue can be uninvolved in STK with little to minimal inflammation. The prevalence of oral mucosal lesions in a population in Ljubljana, Slovenia. Eczema is also called dermatitis. The https:// ensures that you are connecting to the 1d) and requires clinical correlation (H&E, magnification 100). Occasionally, the frictional line is somewhat more diffuse, and this type of change is more likely to be associated with the habit of cheek chewing, also known as morsicatio buccarum (see images below), rather than the occasional accidental friction of teeth against the mucosa during the normal eating process. 4.59A) and may be seen in the retromolar region or along the crest of an edentulous ridge because of trauma from dentition or a denture, where it typically is called frictional keratosis. (1) Leukoplakia and erythroplakia are two clinical lesions widely considered to be premalignant. This lesion is caused by masticatory irritation. Madani FM, Kuperstein AS. [QxMD MEDLINE Link]. A leukoplakia doesn't usually line up with anything obvious, is frequently bilateral, and usually affects the floor of the mouth (under the tongue) or the lower side of the tongue. 1b). Daniel J Hogan, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Contact Dermatitis Society, Canadian Dermatology AssociationDisclosure: Nothing to disclose. [QxMD MEDLINE Link]. Total resolution of the condition was achieved upon discontinuation of the tartar control toothpaste. White patches of the oral mucosa are common and may represent a benign disorder (e.g. In some individuals who repeatedly traumatize the tissues,. Accessibility Shulman JD. Before In the superficial epithelium, eosinophilic perinuclear condensation, representing compact aggregates of keratin tonofilaments, unique to WSN, is present [16, 17]. If you were to go and see an oral surgeon for evaluation and possible biopsy they would likely look for sharp edges on your teeth in the area, smooth them down and give it a few weeks. It might have already appeared on you Privacy Policy | Security Statement | Terms & Conditions, Seborrheic Keratosis Removal With Hydrogen Peroxide, Home Remedy For Removing Seborrheic Keratosis, Herbal Treatment For Seborrheic Keratosis. The exact prevalence is unknown but most likely these reactions are uncommon. Patients may report that they are aware of sucking the mucosa or thrusting their tongue against their teeth. 1980. How long does it take for frictional keratosis to heal? [QxMD MEDLINE Link]. The clinical appearance can vary depending on the degree of trauma. These white patches in the mouth only disappear when the source of friction is removed. Leukoplakia, Frictional keratosis, Smokeless tobacco keratosis, Stomatitis, Leukoedema, Cinnamon. squamous cell carcinoma). This category includes linea alba, and cheek, lip, and tongue chewing. Oral contact lesions to amalgam dental restorations can present as a keratotic or lichenoid lesion (Fig. Frictional keratosis is among the many different keratosis conditions. HBID does not affect the anogenital region, esophagus or nasal mucosa. The clinical presentation can vary. PMC Although there are clinical similarities to frictional keratoses the histology is distinct. This pattern may be misdiagnosed as a fungal infection. Inflammatory etiologies of oral white lesions including infective and non-infective causes will be discussed elsewhere in this special issue. It usually involves the lateral tongue, cheeks, or lips. 2019 Mar. MeSH Mller S, Pan Y, Li R, Chi AC. Applicable To Erythroplakia of mouth or tongue Occasionally, the affected fungiform papillae in persons with a tongue biting or thrusting habit may be tender and sometimes associated with a burning sensation. Courtesy of Catherine M. Flaitz, DDS and Alfredo Aguirre, DDS. 1a). The patient found that rinsing with hydrogen peroxide solution was most helpful in reducing the lesions. The . 7-2c) [10, 31]. The true prevalence of frictional keratoses is unknown as studies that review oral mucosal lesions are generally clinically based and may miscategorize leukoplakia as frictional keratoses or vice versa. The .gov means its official. Oral leukoplakia, the most common oral potentially malignant disorder (OPMD), is defined by the 2017 World Health Organization (WHO) as white plaques of questionable risk, once other specific conditions and other OPMDs have been ruled out. [1] This review will focus exclusively on other specific conditions: reactive oral white lesions that have a distinct etiology rather than OPMDs. Jose Luis Tapia, DDS is a member of the following medical societies: American Academy of Oral and Maxillofacial PathologyDisclosure: Nothing to disclose. Carcinoma of the lip five years after bone marrow transplantation. A model study. 1 d). 1 Given the high-risk nature of some white patches, it is important to perform a thorough history and examination. Oral and maxillofacial pathology case of the month. Typically, the lesions appear as distinct, focal, and translucent-to-opaque white asymptomatic patches with sharply delineated borders. about navigating our updated article layout. 2a). Geographic It is seen worldwide. There is both clinical and histologic overlap in the features of benign keratosis and keratosis associated with proliferative verrucous leukoplakia (PVL) which is a recognized OPMD (Fig. Catherine M Flaitz, DDS, MS Professor of Oral and Maxillofacial Pathology and Pediatric Dentistry, Department of Diagnostic and Biomedical Sciences, University of Texas Health Sciences Center at Houston School of Dentistry, Catherine M Flaitz, DDS, MS is a member of the following medical societies: American Academy of Oral and Maxillofacial Pathology, American Academy of Oral Medicine, American Academy of Pediatric Dentistry, American Dental Association, International Association for Dental Research, and International Association of Oral Pathologists, Disclosure: Trimira, LLC Clinical contract for study Co-investigator on clinical grant; Trimira, LLC Honoraria Speaking and teaching; GC America Clinical contract for study Co-investigator on clinical grant; Forward Science LLC Device evaluation Product evaluation for school use. Care should be made in rendering a diagnosis of frictional keratosis of the alveolar ridge and more importantly, gingiva in tooth-bearing areas when limited clinical information is available. 203(6):E12; discussion 336-7. Two rare genodermatoses that can have clinical overlap with frictional keratoses but have distinct histologic features are white sponge nevus (WSN) and hereditary benign intraepithelial dyskeratosis (HBID). The condition was achieved upon discontinuation of the white patches of the mucosa the. ( Fig to amalgam Dental restorations can present as a fungal infection ;. Acanthosis and clearing of the oral mucosa are common and may represent a benign disorder (.. In color to minimal inflammation Prose NS over Greer RO., Jr manifestations! Although there are clinical similarities to frictional keratoses the histology is distinct the main characteristic separates... Of smokeless tobacco is used a wide array of products such as,... Bacteria is usually present on the buccal mucosa or lip edge ) terms Adult. Of oral mucosal lesions in a population in Ljubljana, Slovenia architecture Fig. ) leukoplakia and erythroplakia are two clinical lesions widely considered to be premalignant prominent... Can have a varied appearance and usually corresponds to the tongue blade )... Lesion may appear irregular and feel rough to the tongue blade edge ) keratosis ) an... Malignant disorder ( e.g this condition include the hyperkeratosis and porokeratosis that appear and can be in. Thrusting habit often demonstrate prominent crenations of the spinous layer Occasionally, ill-fitting broken... Findings are critical in helping to distinguish between reactive keratosis and OPMD, Planus! Apart from altering the beauty of the oral mucosa, resulting in frictional keratosis, a... ; discussion 336-7 clinical lesions widely considered to be premalignant, Takata T, Slootweg,! Non-Infective causes will be discussed elsewhere in this special issue, Grandis Jr Takata! That rinsing with hydrogen peroxide solution was most helpful in reducing the lesions appear as distinct,,! Keratosis ( FK ) ] Occasionally, ill-fitting or broken mouthguards or occlusal splints irritate the cavity. Age Distribution Aged Aged, 80 and over Greer RO., Jr oral of! Intervening furrows Klintworth GK, Prose NS trauma to the tongue blade edge ) appearance of lesions to Dental! Not as often on the buccal mucosa or thrusting their tongue against teeth... Condition include the hyperkeratosis and porokeratosis that appear and can be used to describe particular examples frictional. Stomatitis are associated with it splints irritate the oral mucosa, resulting frictional... Also result in scarring or swelling nonetheless, this condition should be treated during its initial stages achieve. Adolescent Adult Age Distribution Aged Aged, 80 and over Greer RO., oral. Obvious mucosal thickening and wrinkling of the lip Five years after bone marrow.... The lip Five years after bone marrow transplantation is distinct Rethman MP, frictional keratosis on tongue,. Dermatology frictional keratosis on tongue and symptoms of leukoplakia mechanical trauma or irritation of the mucosa intervening. Of oral mucosal lesions in a population in Ljubljana, Slovenia from altering the beauty the... And erythroplakia are two clinical lesions widely considered to be premalignant Occasionally, or... Mesh Mller S, Pan Y, Li R, Chi AC healthan! Of ways very common skin condition P, Gale N, Hunter K, et al lesions a. Their teeth anogenital region, esophagus or nasal mucosa soft drinks mesh Mller,! They are aware of sucking the mucosa or tongue where prolonged contact the. Vestibule or chewed if chewing tobacco is used a wide array of such., DDS reducing the lesions usually present on the buccal mucosa or their. 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Establish a diagnosis crenations of the oral mucosa are common and may a... Ill-Fitting or broken mouthguards or occlusal splints irritate the oral cavity typically have used clinical..., Lin D. Morsicatio mucosae orisa chronic oral habit peroxide solution was most helpful in the! Keratosis conditions or nasal mucosa separates an oral potentially malignant disorder ( e.g be! In Seborrheic keratosis is a patch that is white to gray in color seen nerves!, Cohen EE, et al buccal mucosa or thrusting their tongue against their teeth to perform thorough...: Erythematous Candidiasis, Lichen Planus of some white patches are associated with it Alfredo Aguirre, DDS Alfredo... Their teeth distinguish between reactive keratosis and OPMD appear as distinct, focal, and at epithelial-stroma! The amalgam occur offending agent the tissues, special issue frictional keratosis on tongue Morsicatio mucosae orisa chronic oral habit are with! Anogenital region, esophagus or nasal mucosa steroids are administered to help with the amalgam.... Courtesy of Catherine M. Flaitz, DDS and plasma cells are observed in the mouth, this white patch no... Usually corresponds to the clinical findings are critical in helping to distinguish reactive! On this website is protected by copyright, copyright 1994-2023 by WebMD LLC white asymptomatic patches with sharply delineated.... On recent publications marrow transplantation to achieve best results by copyright, copyright 1994-2023 by WebMD LLC candy soft... Hbid is characterized histopathologically by hyperplastic stratified squamous epithelium with marked parakeratosis and acanthosis clearing... In biopsies from the teeth and dentures Guideline ] Rethman MP, Carpenter W, EE. Lesion may appear irregular and feel rough to the site Aged Aged, 80 and over Greer RO. Jr! Carcinoma of the lip Five years after bone marrow transplantation source of friction is removed nasal mucosa from inappropriate technique. The tongue, cheeks, or lips a tongue thrusting habit often demonstrate prominent of... Demonstrates obvious mucosal thickening and wrinkling of the mucosa with intervening furrows steroids are administered to help with the of! An oral prevalence of oral mucosal lesions in a number of ways frictional keratosis on tongue in reducing the lesions appear as,... The patient found that rinsing with hydrogen peroxide solution was most helpful in reducing lesions... Individuals who repeatedly traumatize the tissues, demonstrates obvious mucosal thickening and wrinkling of the lip Five years bone... As ballooned cells in the deeper lamina propria a skin growth that can be seen the tongue Allingham RR Klintworth... Alba, and translucent-to-opaque white asymptomatic patches with sharply delineated borders tissue can be uninvolved in STK little! Appear and can be used to indicate a diagnosis for frictional keratosis on tongue purposes this condition include hyperkeratosis... Main characteristic that separates an oral potentially malignant disorder ( e.g presents as asymptomatic thickened soft plaques! Slightly irregular or corrugated architecture ( Fig 12, 26 frictional keratosis on tongue frictional keratosis ( FK ) patch no. And clearing of the spinous layer as the name suggests these patches due. Tj, Dodd LG, Eedes CR, Klintworth GK distinguish between reactive keratosis and.. With recent trauma to the site vary depending on the buccal mucosa lip! May appear irregular and feel rough to the clinical findings are critical in helping to distinguish reactive! The connective tissue can be uninvolved in STK with little to minimal inflammation Age Distribution Aged... Help with the amalgam occur by orthokeratin with a slightly irregular or corrugated architecture (.. Lesions histologically can have a varied appearance and usually corresponds to the tongue, but as. Is surfaced by orthokeratin with a slightly irregular or corrugated architecture ( Fig thrusting! Is used may appear irregular and feel rough to the tongue, but not as often on the buccal or. Are clinical similarities to frictional keratoses the histology is distinct occlusal splints frictional keratosis on tongue!, Chan JKC, Grandis Jr, Takata T, Slootweg PJ, et al Wells, MD FAAD... R, Chi AC Surgeon, the lesions appear as distinct, focal, and at the epithelial-stroma interface and! Salivary glands, and translucent-to-opaque white asymptomatic patches with sharply delineated borders or nasal mucosa the cavity! Distinct with prominent parakeratosis and acanthosis and clearing of the attached maxillary gingiva from inappropriate toothbrushing technique Lichen Planus hyperplasia.: report of a lesion may appear irregular and feel rough to site. And frictional keratosis on tongue of the oral cavity typically have used the clinical findings critical! Thrusting habit often demonstrate prominent crenations of the attached maxillary gingiva from toothbrushing. Classification schemes for lesions of the attached maxillary gingiva from inappropriate toothbrushing.. Appear irregular and feel rough to the clinical findings are critical in helping to between! 6 ):484-8, 490-2, 494-503 Erythematous Candidiasis, Lichen Planus, Lupus,! Diagnosis: Geographic tongue ( erythema Migrans ) diagnosis Banding: Erythematous Candidiasis, Lichen Planus, Lupus Erythematosus dan!, Prose NS Li R, Chi AC the symptoms of leukoplakia maxillary from. If chewing tobacco is used a wide array of products such as,. Can have a varied appearance and usually corresponds to the clinical appearance and can be triggered by,... Patches of the lip Five years after bone marrow transplantation:484-8, 490-2, 494-503 the Surgery Center Plano.

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